Comprehensive Analysis of Psychological, Social and Clinical Aspects of Polycystic Ovary Syndrome in Pregnancy: Insights From the Born in Bradford Cohort Study
Main finding · GHQ-28 score (overall well-being and psychological distress)Result — go to the resultβ 2.65Authors' conclusion
The findings underscore the importance of considering demographic, social, and clinical factors in the management of pregnant women with PCOS.
Study context
- Population
- Pregnant women in the Born in Bradford (BiB) cohort
- Participants
- 279 vs 10,284
- Exposure
- Pregnant women with polycystic ovary syndrome (PCOS) vs controls
- PCOSn = 279
- Controlsn = 10,284reference
- Outcome
- GHQ-28 score (overall well-being and psychological distress)
Main finding
As reported in the abstract
β
2.65
P = 0.002
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Pre-eclampsia | 2.09 (1.18–3.71) | P = 0.01 | |
| Gestational hypertension | 1.69 (1.19–2.38) | P = 0.005 | |
| Stillbirth | 4.93 (1.92–12.62) | P = 0.005 | |
| 0.050.21520Odds ratio (log scale) |
Pre-eclampsia
- After adjusting for BMI, association no longer significant; mediation analysis confirmed a significant mediating role of BMI
Birth weight
- Reduction particularly pronounced in female infants
- P = 0.004
- No significant difference in male infants
- P > 0.05
- Lower overall birth weights in infants of mothers with PCOS
- Gender-stratified analysis
Original publication
Comprehensive Analysis of Psychological, Social and Clinical Aspects of Polycystic Ovary Syndrome in Pregnancy: Insights From the Born in Bradford Cohort Study. Clin Endocrinol (Oxf). Published 10 April 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →