Comparison of two titration programmes for adding insulin detemir to oral antidiabetic drugs in patients with poorly controlled type 2 diabetes mellitus
Authors' conclusion
Addition of basal insulin using active titration for 24 weeks provided a higher rate of HbA1c target achievement without significant hypoglycaemia compared to usual titration in individuals with uncontrolled type 2 diabetes.
Study context
- Population
- Patients with T2D uncontrolled with oral antidiabetic drugs (OADs)
- Participants
- 172 patients
- Comparison
- Active insulin titration vs usual titration of insulin detemir added to OADs
- Primary endpoint
- Change in HbA1c
- Follow-up
- Week 24
Methodological detailsprospective
- Prospective
Primary result
As reported in the abstract
Active titration
−1.08
± 1.60% · %
Usual titration
−0.95
± 1.34% · %
P = 0.569
Further findings
Achieving HbA1c<53 mmol/mol
P = 0.037
Predictors of achieving HbA1c<53 mmol/mol (multivariate logistic regression)
- With active titration, baseline HbA1c and postprandial glucose excursion were significantly associated with achieving HbA1c<53 mmol/mol
Safety
- No significant difference in the incidence of hypoglycaemia between the two groups
Original publication
Comparison of two titration programmes for adding insulin detemir to oral antidiabetic drugs in patients with poorly controlled type 2 diabetes mellitus. Diabetes Obes Metab. Published 25 November 2022. doi:10.
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