Comparison of Intranasal and Injectable Glucagon Administration Among Pediatric Population Responders
Authors' conclusion
Nasal glucagon is faster to use, more likely to be successfully administered, and more acceptable than IG for parents of children with T1D and school workers.
Study context
- Population
- Parents of youth with T1D and school workers, 3 months after watching short pedagogical videos30 parents · 30 school workers
- Comparison
- Nasal glucagon vs injectable glucagon (IG)
- Primary endpoint
- Completion time and successful execution of critical steps in simulated administration
Methodological detailssimulated scenarios, each participant administered both glucagon formulations
- Simulated scenarios
- Each participant administered both glucagon formulations
Primary result
As reported in the abstract
Completion time
- Both groups administered nasal glucagon faster than IG
- Nasal glucagon vs IG: P < 0.001
- Nasal glucagon vs IG: P < 0.001
Further findings
Successful execution of all critical steps · School workers
P = 0.007
Successful execution of all critical steps · Parents
P = 0.227
Successful execution of all critical steps
- Lower proportion succeeded with IG vs nasal glucagon; significant for school workers, not parents
Preference and learning modality
- Nasal glucagon preferred for ease of use and acceptability
- Preferred learning: videos plus workshops; videos alone could suffice for nasal glucagon
Original publication
Comparison of Intranasal and Injectable Glucagon Administration Among Pediatric Population Responders. Diabetes Technol Ther. Published 7 November 2023. doi:10.
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