Comparative Weight Change With Initiation and Adherence to Common Medications for Type 2 Diabetes
Authors' conclusion
Initiation/adherence to GLP-1RAs and SGLT-2s over 24 months could result in average weight losses of 5.15 kg and 6.71 kg, respectively.
Study context
- Population
- Adults aged 20 to <80 years with T2D prescribed metformin
- Participants
- 22,601 adults
- Comparison
- Initiation/adherence to DPP-4i, GLP-1 RA, SGLT2i, long-acting insulin or SU added to metformin
- Outcome
- Average weight change
- Follow-up
- 24 months
Methodological detailsinverse probability weighting of marginal structural models, standardization by baseline covariates
- Inverse probability weighting of marginal structural models
- Standardization by baseline covariates
Main finding
As reported in the abstract
Weight change
GLP-1RAs
−5.15
mean · 95% CI −10.6–-1.36 · kg
SGLT-2
−6.71
mean · 95% CI −8.38–-4.34 · kg
Further findings
| Outcome | Values |
|---|---|
| Weight change with DPP4s · 6 months | DPP4 −0.89 (95% CI −1.41–-0.32) kg |
Weight change with DPP4s · 6 months
- No weight loss for DPP4s at 12 months
Weight change with glimepiride · 6 and 12 months
kg
- Weight gain with glimepiride at 6 months
- 0.88 (95% CI 0.44, 1.22)
- Weight gain with glimepiride at 12 months
- 1.01 (95% CI 0.32, 1.51)
Original publication
Comparative Weight Change With Initiation and Adherence to Common Medications for Type 2 Diabetes. Obesity (Silver Spring). Published 16 October 2025. doi:10.
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