Comparative Effectiveness of Individual Sodium-Glucose Cotransporter 2 Inhibitors
Authors' conclusion
This study found that individual SGLT-2 inhibitors demonstrated comparable cardiovascular effectiveness at clinically effective doses, though low-dose dapagliflozin showed a reduced benefit for heart failure hospitalization compared with empagliflozin.
Study context
- Population
- Adults with T2D in 3 US claims databases, August 2014 through June 2020
- Participants
- 232,890 / 129,881 / 295,043
- Comparison
- Canagliflozin or dapagliflozin vs empagliflozin
- Canagliflozinn = 232,890
- Dapagliflozinn = 129,881
- Empagliflozinn = 295,043reference
- Outcome
- MI/stroke
Methodological details3 US claims databases, propensity score matching-weights, fixed-effect meta-analysis across databases
- 3 US claims databases
- Propensity score matching-weights
- Fixed-effect meta-analysis across databases
Pooled result
As reported in the abstract
Each group vs empagliflozinHazard ratio (95% CI)
Canagliflozin
0.98(0.91–1.05)
Dapagliflozin
0.95(0.89–1.03)
Further pooled results
| Outcome | HR (95% CI) | |
|---|---|---|
| HF hospitalizationDapagliflozinvs EmpagliflozinConsistent across subgroups of CVD history | 1.19 (1.02–1.39) | |
| HF hospitalization, dapagliflozin low dose 5 mgDapagliflozinvs EmpagliflozinLow dose of 5 mg | 1.30 (1.12–1.50) | |
| 0.512Hazard ratio (log scale) |
Safety
| Outcome | HR (95% CI) | |
|---|---|---|
| Genital infectionsCanagliflozinvs Empagliflozin | 0.94 (0.91–0.97) | |
| Genital infectionsDapagliflozinvs Empagliflozin | 0.92 (0.89–0.95) | |
| Severe UTICanagliflozinvs Empagliflozin | 1.13 (1.03–1.24) | |
| DKADapagliflozinvs Empagliflozin | 0.78 (0.68–0.90) | |
| 0.512Hazard ratio (log scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Comparative Effectiveness of Individual Sodium-Glucose Cotransporter 2 Inhibitors. JAMA Intern Med. Published 1 March 2025. doi:10.
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