Common and ethnic-specific derangements in skeletal muscle transcriptome associated with obesity
Authors' conclusion
This study provides a replication of obesity-associated transcripts and biological pathways in skeletal muscle across ethnicities, but also identifies obesity-associated processes unique in either African or European ancestry populations.
Study context
- Population
- Human skeletal muscle tissue from European and African ancestry cohorts
- Participants
- 301 vs 256
- Exposure
- Body mass index (BMI)-associated skeletal muscle transcripts in European vs African American ancestry cohorts
- FUSIONn = 301
- AAGMExn = 256
- Outcome
- BMI-associated skeletal muscle transcripts
Methodological detailstwo-cohort comparison, integration with GWAS-identified SNPs
- Two-cohort comparison
- Integration with GWAS-identified SNPs
Main finding
As reported in the abstract
BMI-associated transcripts identified in total (q < 0.05)
2569
Genes associated in both cohorts (p < 0.05), majority with same direction of effect on BMI
970
Critical target genes (e.g., GRB14) through which GWAS-identified SNPs might cause obesity in muscle
316
Observational data: associations, not effects.
Original publication
Common and ethnic-specific derangements in skeletal muscle transcriptome associated with obesity. Int J Obes (Lond). Published 22 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →