Combining diabetes, sex, and menopause as meaningful clinical features associated with NASH and liver fibrosis in individuals with class II and III obesity: A retrospective cohort study
Authors' conclusion
This study unveiled a remarkably high prevalence of advanced SLD after menopause in women with T2D, associated with a dysfunctional biological liver profile.
Study context
- Population
- Individuals with obesity (class II and III) from the ABOS cohort, with liver histology
- Participants
- 1,446 individuals
- Exposure
- Subgroups by T2D, sex and menopausal status
- Outcome
- Prevalence of NASH and liver fibrosis (F ≥ 2) within each subgroup
Methodological detailshierarchical clustering, liver histology and transcriptome profiling
- Hierarchical clustering
- Liver histology and transcriptome profiling
Main finding
As reported in the abstract
- NASH prevalence, overall
- 9.5% (N = 138/1446)
- F ≥ 2 prevalence, overall
- 11.7% (N = 159/1365)
- NASH prevalence, T2D
- 20.3% (N = 107/726)
- F ≥ 2 prevalence, T2D
- 21.1% (N = 106/502)
- NASH prevalence, non-T2D
- 3.4% (N = 31/920)
- F ≥ 2 prevalence, non-T2D
- 6.1% (N = 53/863)
Observational data: associations, not effects.
Further findings
Interaction between sex and age for NASH among T2D
- P for interaction (sex × age), NASH in T2D
- P = 0.048
NASH-associated biological traits and liver genes
- Lower platelet count, higher uric acid, GGT, AST and liver AKR1B10 and CCL20 expression significantly associated with menopause in women with T2D but not with age in men with T2D
Original publication
Combining diabetes, sex, and menopause as meaningful clinical features associated with NASH and liver fibrosis in individuals with class II and III obesity: A retrospective cohort study. Obesity (Silver Spring). Published 21 November 2023. doi:10.
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