Colorectal Cancer and Subsequent Diabetes Risk: A Population-Based Cohort Study in Taiwan
Main finding · DMResult — go to the resultHazard ratio 1.14 95% CI 1.09–1.20Authors' conclusion
Patients with CRC are associated with an elevated risk of diabetes mellitus, and long-term chemotherapy, particularly involving capecitabine, increases diabetes mellitus risk. Thus, monitoring blood glucose levels is crucial for patients with CRC, especially during extended chemotherapy.
Study context
- Population
- Patients with colorectal cancer (CRC) in the Taiwan Cancer Registry (2007–2018) linked with health databases, and matched general populationmatched cohort
- Participants
- 86,268 vs 86,268
- Exposure
- CRC vs matched general population
- CRCn = 86,268
- General populationn = 86,268reference
- Outcome
- New-onset DM
Methodological detailsnationwide, propensity score-matched
- Nationwide
- Propensity score-matched
Main finding
DM
Hazard ratio
1.14
95% CI 1.09–1.20
CRCvs General population
HR 1.14 (95% CI 1.09–1.20)
As reported in the abstract
Observational data: associations, not effects.
Further findings
DM by chemotherapy exposure within 3 years of diagnosis (no chemotherapy, <90 days, 90 to 180 days, >180 days), CRC patients 2007-2016 (n = 37 277)
| HR (95% CI) | ||
|---|---|---|
| Long-term chemotherapy (>180 days)60% to 70% increased risk of subsequent DM | 1.64 (1.07–2.49) | |
| 0.512Hazard ratio (log scale) |
Original publication
Colorectal Cancer and Subsequent Diabetes Risk: A Population-Based Cohort Study in Taiwan. J Clin Endocrinol Metab. Published 25 April 2024. doi:10.
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