Cold exposure modulates potential brown adipokines in humans, but only FGF21 is associated with brown adipose tissue volume
Authors' conclusion
Cold exposure modulates plasma levels of several potential brown adipokines in humans, whereas only cold-induced changes in FGF21 levels are associated with BAT volume. These findings suggest that human BAT might contribute to the circulatory pool of FGF21.
Study context
- Population
- Young adults (60% women, 21.9 ± 2.3 y; 24.9 ± 5.1 kg/m²) undergoing individualized cold exposure
- Participants
- 30 adults
- Outcome
- Plasma levels of potential brown adipokines (CXCL14, GDF15, FGF21, IL6, BMP8b) and relation of cold-induced changes to BAT volume, activity or radiodensity
- Follow-up
- Before and 1 h and 2 h after starting cold exposure
Methodological detailsBrown adipose tissue (BAT) volume, 18F-fluorodeoxyglucose uptake and radiodensity assessed by static PET-CT scan after cold exposure
- BAT volume, 18F-fluorodeoxyglucose uptake and radiodensity assessed by static PET-CT scan after cold exposure
Main finding
As reported in the abstract
Cold-induced change in plasma brown adipokines
- CXCL14 increased (Δ2h, ng/mL; p = 0.007)
- 0.58 ± 0.98
- GDF15 increased (Δ2h, pg/mL; p = 0.013)
- 19.63 ± 46.2
- FGF21 increased (Δ2h, pg/mL; p = 0.003)
- 33.72 ± 55.13
- IL6 increased (Δ1h, pg/mL; p = 0.048)
- 1.98 ± 3.56
- BMP8b reduced (Δ2h, pg/mL; p = 0.022)
- −37.12 ± 83.53
- Cold-induced FGF21 increase vs BAT volume (Δ2h: β; R2 = 0.307; p = 0.001)
- 0.456
Original publication
Cold exposure modulates potential brown adipokines in humans, but only FGF21 is associated with brown adipose tissue volume. Obesity (Silver Spring). Published 22 January 2024. doi:10.
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