Cognition in patients with mild autonomous cortisol secretion at baseline and post-adrenalectomy
Authors' conclusion
Patients with MACS demonstrate lower cognition than referent subjects. Adrenalectomy for MACS had a minor positive impact on cognition.
Study context
- Population
- Adults with mild autonomous cortisol secretion (MACS) (median age 57 years, 67% women) and referent subjects (median age 63 years, 58% women)
- Participants
- 84 vs 201
- Exposure
- Patients with MACS vs referent subjects; cognition before and after adrenalectomy
- MACSn = 84
- Referentn = 201reference
- Outcome
- Cognition (NIH Toolbox Cognition Battery; age-, sex-, race/ethnicity- and education-adjusted T scores for fluid, crystallized and total composite cognition)
Methodological detailsCross-sectional study 4/2019 to 10/2022; longitudinal cohort study 10/2021 to 9/2023
- Cross-sectional study 4/2019 to 10/2022; longitudinal cohort study 10/2021 to 9/2023
Main finding
As reported in the abstract
Total composite cognition T score · baseline
MACS
50.9
mean · SD 9.3
Referent
55.4
mean · SD 8.9
P < 0.001
Observational data: associations, not effects.
Further findings
Mean
| Outcome | MACS | Referent | P value |
|---|---|---|---|
| Fluid composite T score · baselineLower with MACS | 49.3 (SD 10.6) | 55.2 (SD 10.2) | P < 0.001 |
| Crystallized composite T score · baseline | 52.3 (SD 8.4) | 54.0 (SD 8.4) | P = 0.130 |
Change in cognition post-adrenalectomy (37 MACS patients vs 31 referent subjects reassessed)
- Adjusted group differences of cognition change were similar, except a higher comparative increase in attention and executive functioning with MACS
Original publication
Cognition in patients with mild autonomous cortisol secretion at baseline and post-adrenalectomy. Eur J Endocrinol. Published 13 December 2024. doi:10.
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