Adrenalectomy Reduces the Risk of Vertebral Fractures in Patients With Mild Autonomous Cortisol Secretion
Authors' conclusion
In patients with AI and MACS, adrenalectomy significantly reduces the risk of VFx.
Study context
- Population
- Patients with AI >1 cm and mild autonomous cortisol secretion (MACS) (cortisol after 1-mg dexamethasone suppression test ≥1.8 µg/dL [50 nmol/L])Study 1: 53
- Participants
- 31 / 22 / 21 / 28
- Comparison
- Adrenalectomy vs conservative treatment
- Study 1-Group An = 31
- Study 1-Group Bn = 22reference
- Study 2-Group An = 21
- Study 2-Group Bn = 28reference
Methodological detailstwo studies: retrospective (Study 1) and prospective randomized (Study 2), Study 1 follow-up 35.2 ± 18.6 months; Study 2 follow-up 24 months
- Two studies: retrospective (Study 1) and prospective randomized (Study 2)
- Study 1 follow-up 35.2 ± 18.6 months; Study 2 follow-up 24 months
Primary result
As reported in the abstract
Incidence of VFx · end of follow-up
Study 1-Group B vs Study 1-Group A: P < 0.005 · Study 2-Group B vs Study 2-Group A: P = 0.04
Further findings
Bone mineral density (BMD) at lumbar spine (LS), femoral neck (FN) and total hip (TH) (Study 1) · baseline to end of follow-up
- In both groups, BMD at LS, FN and TH comparable between baseline and end of follow-up
Calcium and phosphorus (Study 2) · 24 months
- Calcium increased vs baseline in Study 2-Group A, not in Study 2-Group B
- P = 0.03
- Phosphorus increased vs baseline in Study 2-Group A, not in Study 2-Group B
- P = 0.04
BMD (Study 2) · end of follow-up
- BMD remained stable across both groups
Original publication
Adrenalectomy Reduces the Risk of Vertebral Fractures in Patients With Mild Autonomous Cortisol Secretion. J Clin Endocrinol Metab. Published 11 April 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →