Coadministered Cagrilintide and Semaglutide in Adults with Overweight or Obesity
Primary result · Mean % change in body weightResult — go to the resultEstimated difference −17.3 percentage points 95% CI −18.1 to −16.6Authors' conclusion
Cagrilintide-semaglutide provided significant and clinically relevant body-weight reductions in adults with overweight or obesity, as compared with placebo.
Study context
- Population
- Adults without diabetes with body-mass index (BMI) ≥30, or BMI ≥27 with ≥1 obesity-related complicationrandomized 21:3:3:7
- Participants
- 3,417 adults
- Comparison
- Cagrilintide-semaglutide vs placebo
- Cagrilintide-semaglutiden = 2,108
- Semaglutiden = 302
- Cagrilintiden = 302
- Placebon = 705reference
- Primary endpoint
- Coprimary: relative change in body weight and body-weight reduction ≥5%, cagrilintide-semaglutide vs placebo
- Follow-up
- Baseline to week 68
Methodological detailsphase 3a, multicenter, double-blind, placebo-controlled, active-controlled
- Phase 3a
- Multicenter
- Double-blind
- Placebo-controlled
- Active-controlled
Primary result
Mean % change in body weight
Estimated difference
−17.3 percentage points
95% CI −18.1 to −16.6
P < 0.001
Change by group
Cagrilintide-semaglutide
−20.4%
mean
Placebo
−3.0%
mean
Cagrilintide-semaglutidevs Placebo
estimated difference −17.3 percentage points (95% CI −18.1 to −16.6); P < 0.001
As reported in the abstract
Secondary outcomes
| Outcome | P value |
|---|---|
| Body-weight reductions ≥20%, ≥25% and ≥30% (confirmatory secondary)Cagrilintide-semaglutide vs Placebo · more likely with cagrilintide-semaglutide | P < 0.001 for all comparisons |
Safety
| Outcome | Cagrilintide-semaglutide | Placebo |
|---|---|---|
| Gastrointestinal adverse events | 79.6% | 39.9% |
Gastrointestinal adverse events
- Mainly transient and mild-to-moderate in severity
Original publication
Coadministered Cagrilintide and Semaglutide in Adults with Overweight or Obesity. N Engl J Med. Published 22 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →