Clustering of intuitive eating and psychological health identifies subgroups associated with weight loss following semaglutide
Authors' conclusion
Psychological and behavioral clusters identified through HADS and IES-2 are associated with weight loss under semaglutide treatment, suggesting the value of integrating psychological and behavioral profiling into obesity care.
Study context
- Population
- Adults with BMI ≥ 25 kg/m² (Aviitam platform, France); Phase 3: individuals with BMI ≥ 40 kg/m² treated with semaglutide 2.4 mg/week at Montpellier University HospitalPhase 1
- Participants
- 989 adults
- Exposure
- Intuitive Eaters Group (IEG) vs Emotionally Driven Eaters Group (EDEG) clusters
- IEGn = 482
- EDEGn = 507reference
- Outcome
- Weight-loss trajectory under semaglutide (Phase 3)
- Follow-up
- 12 months
Methodological detailsthree-phase design, clustering, validation phase
- Three-phase design
- Clustering
- Validation phase
Main finding
As reported in the abstract
- IEG vs EDEG: P = 0.03
- Phase 3: 125 individuals
Observational data: associations, not effects.
Further findings
Cluster discrimination by Hospital Anxiety and Depression Scale (HADS) and IES-2
- AUC
- 0.95
- IEG had lower emotional distress and higher intuitive eating scores
Cluster robustness (Phase 2)
- Robustness was confirmed in Phase 2
- 492 individuals
Original publication
Clustering of intuitive eating and psychological health identifies subgroups associated with weight loss following semaglutide. Obesity (Silver Spring). Published 3 April 2025. doi:10.
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