Closed-loop insulin delivery for glycaemic control in hospitalised and perioperative adults: A systematic review and meta-analysis of randomised controlled trials
Authors' conclusion
Closed-loop insulin delivery may improve glycaemic process measures
Study context
- Population
- Hospitalised and perioperative adults7 trials, analysed
- Participants
- 375 participants
- Comparison
- Closed-loop or automated insulin delivery vs usual care or conventional insulin therapy
- Outcome
- Glycaemic control
Methodological detailsrandom-effects meta-analysis, RoB 2, GRADE
- Random-effects meta-analysis
- RoB 2
- GRADE
Pooled result
As reported in the abstract
Closed-loop vs Usual careDifference in time in target glucose range, percentage points (95% CI)
I2 = 0%; moderate certainty
23.91(19.40–28.43)
- I2 = 36.3%; moderate certainty
- reduction in mean glucose 1.79 mmol/L (95% CI 1.06 to 2.53 lower)
Further pooled results
Clinically significant hyperglycaemia
- 2 trials (69 participants); both estimates favoured closed-loop; exploratory and imprecise
Safety
Events
| Outcome | Closed-loop | Usual care |
|---|---|---|
| Severe hypoglycaemiaPrecluding reliable estimation of comparative safety | 0 | 0 |
Original publication
Closed-loop insulin delivery for glycaemic control in hospitalised and perioperative adults: A systematic review and meta-analysis of randomised controlled trials. Diabetes Res Clin Pract. Published 25 August 2026. doi:10.
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