Clinically significant hypoglycaemia in hospitalised adults: A multicentre study of 1205 episodes in the United Kingdom
Authors' conclusion
Clinically significant inpatient hypoglycaemia is associated with high mortality and substantial variation in care. The IHSG framework reliably predicts poor outcomes and may serve as a valuable framework for standardised risk stratification and service evaluation. Identification of common, modifiable risk factors highlights opportunities for systematic QI and surveillance.
Study context
- Population
- Hospitalised people with diabetes with clinically significant hypoglycaemia (International Hypoglycaemia Study Group (IHSG) Levels 2 and 3), 11 UK centres, October 2023–December 2024; mean age 72 years, 54.5% male, 74.6% T2D, median Charlson Comorbidity Index 6
- Participants
- 674 people1,205 episodes
- Exposure
- Level 2 vs Level 3
- Outcome
- Inpatient mortality
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
Common precipitants
- Intercurrent illness
- 44.7%
- Fasting/missed meals
- 40.7%
- Medication dosing errors
- 16.7%
Episode characteristics
- Episode characteristics varied by sex, diabetes type and centre
Original publication
Clinically significant hypoglycaemia in hospitalised adults: A multicentre study of 1205 episodes in the United Kingdom. Diabet Med. Published 20 April 2026. doi:10.
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