Clinical presentation and outcomes of sporadic neuroendocrine neoplasms in young adults
Authors' conclusion
Young patients with NENs often present with well-differentiated and localised tumours, thereby increasing the probability of curative surgical resection.
Study context
- Population
- Young adults aged 18–40 years diagnosed with sporadic neuroendocrine neoplasms (NENs) (well and poorly differentiated), 2010–2020; excluded appendiceal and type 1 gastric NETs, hereditary syndromes, synchronous malignancy, pheochromocytoma, paraganglioma and MTC
- Participants
- 478 adults
- Outcome
- Clinical features at presentation
- Follow-up
- Diagnosis
Methodological details20 institutions from 12 countries
- 20 institutions from 12 countries
Main finding
As reported in the abstract
- Localised tumours
- 62%, n = 249
- Well-differentiated tumours
- 92%, n = 433
- Non-functioning tumours
- 81%, n = 384
- Women
- 58%, n = 277
- Pancreas most common primary site
- 33%, n = 159
- Five-year overall survival
- 82%
Observational data: associations, not effects.
Further findings
Metastatic disease at diagnosis by sex
P = 0.004
- Overall survival by sex · significantly longer in women
- P = 0.019
- Overall survival by primary site vs pancreatic NENs · longer in rectal
- P = 0.00245
- Overall survival by primary site vs pancreatic NENs · longer in lung
- P = 0.0027
Independent predictors of survival (Cox multivariable analysis)
- Stage, Ki-67, morphology and gender were independent predictors of survival
Original publication
Clinical presentation and outcomes of sporadic neuroendocrine neoplasms in young adults. Eur J Endocrinol. Published 15 June 2026. doi:10.
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