Clinical features and outcomes of diabetic ketoacidosis in patients using SGLT2 inhibitors: A systematic review and meta‐analysis
Authors' conclusion
These findings provide quantitative evidence of the distinct clinical features of SGLT2i-associated DKA, which may aid in early detection, management, and prevention in clinical practice.
Study context
- Population
- Patients with diabetic ketoacidosis (DKA), studies comparing clinical features or outcomes between SGLT2i users and non-users; PubMed, Scopus, Web of Science searched February 20259 studies
- Comparison
- DKA in SGLT2i users vs non-users
- Outcome
- Clinical features and outcomes of DKA
Pooled result
As reported in the abstract
Clinical features of DKA
- Lower odds of prior DKA and insulin use in SGLT2i users
- Lower glucose, HbA1c, creatinine and lactate levels in SGLT2i users vs non-users
Further pooled results
Outcomes of DKA
- No significant differences in length of hospitalisation, ICU admission or in-hospital mortality
Original publication
Clinical features and outcomes of diabetic ketoacidosis in patients using SGLT2 inhibitors: A systematic review and meta‐analysis. Diabetes Obes Metab. Published 21 July 2025. doi:10.
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