Clinical Characteristics and Risk Factors Associated With Adverse Pregnancy Outcomes in Patients With Gestational Hypothyroidism: A Case-Control Study
Authors' conclusion
Our study revealed that the clinical features of patients with GH were age, gestational diabetes, gestational hypertension, gravidity, parity, spontaneous abortion, history of gestation, thyroid-stimulating hormone, free triiodothyronine, TPO-Ab, and free thyroxine.
Study context
- Population
- Pregnant women with and without gestational hypothyroidism, February 2021 to March 2023
- Participants
- 298 vs 312
- Comparison
- Gestational hypothyroidism vs pregnant women without gestational hypothyroidism
- Gestational hypothyroidism (GH)n = 298
- Controln = 312reference
- Outcome
- Clinical characteristics
Main finding
As reported in the abstract
- Age, gestational diabetes, gestational hypertension, gravidity, parity, spontaneous abortion, history of gestation, TSH, free triiodothyronine, thyroid peroxidase antibody (TPO-Ab) and FT4 differed significantly between the 2 groups
- P <.05
Observational data: associations, not effects.
Further findings
Pregnancy outcomes
- Preterm delivery, preeclampsia, premature rupture of membranes, placental abruption and postpartum hemorrhage differed significantly between the 2 groups
- P < 0.05
Factors influencing pregnancy outcome in GH (multivariate logistic regression)
- Influencing factors: age (≥30 years), gestational diabetes, gestational hypertension, gravidity (≥3 times), spontaneous abortion, parity, history of gestation (multiparity), TPO-Ab (positive)
Original publication
Clinical Characteristics and Risk Factors Associated With Adverse Pregnancy Outcomes in Patients With Gestational Hypothyroidism: A Case-Control Study. Endocr Pract. Published 31 October 2023. doi:10.
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