Circulating Adipocyte Fatty Acid-binding Protein (AFABP), FGF21, and Pigment Epithelium-derived Factor (PEDF) Levels as Prognostic Biomarkers of Sight-threatening Diabetic Retinopathy
Authors' conclusion
Among the 3 diabetes-related biomarkers, serum AFABP level appeared to be a more clinically useful biomarker for predicting incident STDR in type 2 diabetes.
Study context
- Population
- Chinese individuals with T2D without sight-threatening DR (STDR) at baseline; mean diabetes duration 11 years, ≥ 50% with nonproliferative DR at baseline172 developed STDR
- Participants
- 4,760 individuals
- Exposure
- Baseline serum AFABP, FGF21 and PEDF levels as predictors of incident STDR
- Outcome
- Incident sight-threatening DR (STDR)
- Follow-up
- Median 8.8 years
Main finding
As reported in the abstract
Incident STDR · median follow-up 8.8 years
Serum AFABP independently associated with incident STDR, multivariable Cox regression
1.28
HR; 95% CI 1.05–1.55P = .013
Observational data: associations, not effects.
Further findings
Addition of serum AFABP to clinical model (diabetes duration, glycemic control, albuminuria, baseline DR status), participants without DR or with mild DR at baseline
- Improved c statistics
- P < 0.001
- Improved net reclassification index
- P = 0.0027
- Improved integrated discrimination index
- P = 0.033
Original publication
Circulating AFABP, FGF21, and PEDF Levels as Prognostic Biomarkers of Sight-threatening Diabetic Retinopathy. J Clin Endocrinol Metab. Published 28 February 2023. doi:10.
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