Chronotype, Unhealthy Lifestyle, and Diabetes Risk in Middle-Aged U.S. Women : A Prospective Cohort Study
Authors' conclusion
Middle-aged nurses with an evening chronotype were more likely to report unhealthy lifestyle behaviors and had increased diabetes risk compared with those with a morning chronotype. Accounting for BMI, physical activity, diet, and other modifiable lifestyle factors attenuated much but not all of the increased diabetes risk.
Study context
- Population
- Nurses aged 45 to 62 years with no history of cancer, CVD or diabetes in 2009, Nurses' Health Study II, followed until 2017
- Participants
- 63,676 nurses
- Exposure
- Evening and intermediate vs morning chronotype
- Outcome
- Incident diabetes (self-reported, confirmed by supplementary questionnaire)
- Follow-up
- 2009 to 2017
Main finding
As reported in the abstract
Incident diabetes
Each group vs definite morningAdjusted hazard ratio (CI)
Intermediateadjusted for sociodemographic factors, shift work, family history of diabetes
1.21(1.09–1.35)
Definite eveningadjusted for sociodemographic factors, shift work, family history of diabetes
1.72(1.50–1.98)
Definite eveningadjusted for all measured lifestyle and sociodemographic factors
1.19(1.03–1.37)
- Diabetes cases over 469 120 person-years of follow-up
- 1925
Observational data: associations, not effects.
Further findings
| Outcome | HR (CI) | |
|---|---|---|
| Diabetes, definite evening vs definite morning, further adjusted for BMI, physical activity, diet qualityDefinite eveningvs Definite morningFurther adjusted for BMI | 1.31 (1.13–1.50) | |
| Diabetes, definite evening vs definite morning, further adjusted for BMI, physical activity, diet qualityDefinite eveningvs Definite morningFurther adjusted for physical activity | 1.54 (1.34–1.77) | |
| Diabetes, definite evening vs definite morning, further adjusted for BMI, physical activity, diet qualityDefinite eveningvs Definite morningFurther adjusted for diet quality | 1.59 (1.38–1.83) | |
| 0.512Hazard ratio (log scale) |
Unhealthy lifestyle
- Definite evening vs definite morning: more likely to have an unhealthy lifestyle
- 54% (95% CI, 49% to 59%)
Original publication
Chronotype, Unhealthy Lifestyle, and Diabetes Risk in Middle-Aged U.S. Women : A Prospective Cohort Study. Ann Intern Med. Published 12 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →