Childhood adversity and risk of type 2 diabetes in early adulthood: results from a population-wide cohort study of 1.2 million individuals
Authors' conclusion
Individuals who experienced childhood adversity are at higher risk of developing type 2 diabetes in early adulthood. Intervening upon proximal determinants of adversity may help reduce the number of type 2 diabetes cases among young adults.
Study context
- Population
- Individuals born in Denmark 1980–2001, resident in Denmark and without diabetes at age 16 years; five childhood adversity groups (age 0–15 years) across material deprivation, loss or threat of loss, and family dynamics4,860 developed T2D
- Participants
- 1,277,429 individuals
- Exposure
- Childhood adversity groups vs low adversity group
- Outcome
- T2D in early adulthood (16 to 38 years)
- Follow-up
- From age 16 to 31 December 2018
Methodological detailsnationwide register data, Cox proportional hazards and Aalen additive hazards models
- Nationwide register data
- Cox proportional hazards and Aalen additive hazards models
Main finding
As reported in the abstract
T2D, high vs low adversity
High adversity vs Low adversityHazard ratio (95% CI)
Men
2.41(2.04–2.85)
Women
1.58(1.31–1.91)
High adversity vs Low adversityHazard difference, additional cases per 100,000 person-years (95% CI)
Men
36.2(25.9–46.5)
Women
18.6(8.2–29.0)
Observational data: associations, not effects.
Original publication
Childhood adversity and risk of type 2 diabetes in early adulthood: results from a population-wide cohort study of 1.2 million individuals. Diabetologia. Published 20 April 2023. doi:10.
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