Changes in the triglyceride glucose-body mass index estimate the risk of stroke in middle-aged and older Chinese adults: a nationwide prospective cohort study
Authors' conclusion
Substantial changes in the TyG-BMI are independently associated with the risk of stroke in middle-aged and older adults. Monitoring long-term changes in the TyG-BMI may assist with the early identification of individuals at high risk of stroke.
Study context
- Population
- Middle-aged and older Chinese adults, China Health and Retirement Longitudinal Study (CHARLS); mean (SD) age 58.68 (9.51) years, 44.9% men
- Participants
- 4,583 participants
- Exposure
- Triglyceride glucose-body mass index (TyG-BMI) change classes vs consistently low TyG-BMI
- Outcome
- Incident stroke
- Follow-up
- 3 years
Methodological detailsnationally representative, China Health and Retirement Longitudinal Study (CHARLS), K-means clustering of TyG-BMI changes, adjusted logistic regression
- Nationally representative
- China Health and Retirement Longitudinal Study (CHARLS)
- K-means clustering of TyG-BMI changes
- Adjusted logistic regression
Main finding
As reported in the abstract
3 years
Each group vs consistently low TyG-BMIOdds ratio (95% CI)
Moderate TyG-BMI, slow rising
1.01(0.65–1.57)
High TyG-BMI, slow rising
1.62(1.11–2.32)
Highest TyG-BMI, slow declining
1.71(1.01–2.89)
- Incident stroke cases, all participants
- 277 (6.0%)
Observational data: associations, not effects.
Further findings
Cumulative TyG-BMI and stroke risk (restricted cubic spline)
- Nonlinear association
- Passociation = 0.017; Pnonlinearity = 0.012
Weights of TyG-BMI components (weighted quantile sum regression)
- Triglyceride-glucose (TG) primary contributor, weight 2012
- 0.466
- TG primary contributor, weight 2015
- 0.530
Original publication
Changes in the triglyceride glucose-body mass index estimate the risk of stroke in middle-aged and older Chinese adults: a nationwide prospective cohort study. Cardiovasc Diabetol. Published 16 September 2023. doi:10.
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