Changes in HbA1c and diabetes‐specific quality of life following structured type 1 diabetes education: Exploratory latent profile analysis of outcomes in the dose adjustment for normal eating (DAFNE) plus trial
Authors' conclusion
This study suggests that DAFNEplus has significant added benefits in reducing the negative impact of diabetes on QoL for a subgroup of adults with T1D, but not for their HbA1c. This provides important insights for the future real-world implementation of the DAFNEplus programme.
Study context
- Population
- Adults with T1D completing DAFNE or DAFNEplus structured education; clustered on age, HbA1c, hypoglycaemia awareness, diabetes-specific quality of life (QoL), distress, positive well-being, fear of hypoglycaemia and satisfaction with diabetes management2 clusters
- Participants
- 363 adults
- Comparison
- DAFNEplus vs DAFNE structured T1D education, by baseline cluster
- DAFNEplusn = 147
- Primary endpoint
- HbA1c and diabetes-specific QoL in each cluster
- Follow-up
- 6 and 12 months
Methodological detailsexploratory latent profile analysis, multilevel linear regression
- Exploratory latent profile analysis
- Multilevel linear regression
Primary result
As reported in the abstract
Diabetes-specific QoL, first cluster (consistently worse off on clinical and psychological indicators) · 12 months
Adjusted mean difference
0.81
95% CI 0.19–1.43
P = 0.01
Between DAFNE and DAFNEplus
adjusted mean difference 0.81 (95% CI 0.19–1.43); P = 0.01
Original publication
Changes in HbA1c and diabetes‐specific quality of life following structured type 1 diabetes education: Exploratory latent profile analysis of outcomes in the DAFNE plus trial. Diabet Med. Published 8 January 2026. doi:10.
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