Changes in the glycaemia risk index and its association with other continuous glucose monitoring metrics after initiation of an automated insulin delivery system in adults with type 1 diabetes
Authors' conclusion
GRI was highly correlated with various CGM metrics above, but not below target range, both before and after AID initiation.
Study context
- Population
- Continuous glucose monitoring (CGM) users with T1D initiating an automated insulin delivery (AID) system
- Participants
- 185 users
- Exposure
- After vs before AID initiation
- Outcome
- Glycaemia risk index (GRI) and its association with other CGM metrics
Main finding
As reported in the abstract
GRI
Baseline
48.7
± 21.8
After AID
29
± 13
P < 0.001 for all
- Glycaemia risk index (GRI) inversely correlated with TIR before AID initiation
- r = −0.962
- GRI inversely correlated with TIR after AID initiation
- r = −0.961
- GRI correlated with TAR before AID initiation
- r = 0.906
- GRI correlated with TAR after AID initiation
- 0.910
Observational data: associations, not effects.
Further findings
| Outcome | After AID | Baseline | P value |
|---|---|---|---|
| GRI hypoglycaemia component | 1.6 ± 1.7 | 2.7 ± 2.8 | P < 0.001 for all |
| GRI hyperglycaemia component | 15 ± 8.5 | 25.3 ± 14.5 | P < 0.001 for all |
All CGM metrics, 24 h, daytime and night-time
- All CGM metrics improved after AID initiation (P < .001 for all)
- Metrics improved significantly more during night-time than daytime (P < .01)
Original publication
Changes in the glycaemia risk index and its association with other continuous glucose monitoring metrics after initiation of an automated insulin delivery system in adults with type 1 diabetes. Diabetes Obes Metab. Published 10 July 2023. doi:10.
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