Insulin pump therapy in type 1 diabetes is associated with lower indices of Non-Alcoholic Fatty Liver in non-obese women but not men
Authors' conclusion
CSII is associated with lower NAFLD indices in women with T1D. This may relate to the lower peripheral insulin in the context of a permissive hormonal milieu.
Study context
- Population
- T1D patients without alcohol abuse or other liver diseases; Multiple daily injections (MDI) 65% men, continuous subcutaneous insulin infusion (CSII) 50% men
- Participants
- 659 patients
- Exposure
- CSII vs MDI
- CSIIn = 245
- MDIn = 414reference
- Outcome
- Non-Alcoholic Fatty Liver Disease (NAFLD) assessed by Fatty Liver Index (FLI) and Hepatic Steatosis Index (HSI)
Main finding
As reported in the abstract
| Group | Value | Hepatic Steatosis Index (HSI) |
|---|---|---|
| CSII | 20.2 ± 21.2 | 36.2 ± 4.4 |
| MDI | 24.8 ± 24.3 | 37.4 ± 4.4 |
Value
CSII20.2 ± 21.2
MDI24.8 ± 24.3
Hepatic Steatosis Index (HSI)
CSII36.2 ± 4.4
MDI37.4 ± 4.4
- CSII vs MDI: P = 0.003 — lower with CSII
- CSII vs MDI: P = 0.003 — lower with CSII
Observational data: associations, not effects.
Further findings
Waist circumference · lower with CSII
P = 0.026
Plasma TG · lower with CSII
P = 0.035
Daily insulin dose · lower with CSII
P < 0.001
- Fatty Liver Index (FLI) and HSI by sex (CSII vs MDI) · lower with CSII
- P = 0.009
- FLI and HSI by sex (CSII vs MDI) · lower with CSII
- P = 0.033
- FLI and HSI by sex (CSII vs MDI) · not lower
- P = 0.676
- FLI and HSI by sex (CSII vs MDI) · not lower
- P = 0.131
FLI and HSI by sex (CSII vs MDI)
- Women on CSII also had lower daily insulin doses, plasma TG and visceral adiposity index than women on MDI
Original publication
Insulin pump therapy in type 1 diabetes is associated with lower indices of Non-Alcoholic Fatty Liver in non-obese women but not men. Diabetes Res Clin Pract. Published 5 July 2023. doi:10.
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