Central nervous system microstructural alterations in Type 1 diabetes mellitus: A systematic review of diffusion Tensor imaging studies
Authors' conclusion
T1DM is associated with microstructural brain alterations including reduced FA, MD, and AD in widespread brain regions, especially in association with glycemic fluctuations and in adult age.
Study context
- Population
- Individuals with T1D (adult and juvenile) in DTI studies19 studies
- Comparison
- T1D vs controls
- Outcome
- CNS microstructure on DTI
Methodological detailsqualitative synthesis
- Qualitative synthesis
Pooled result
As reported in the abstract
- Most studies: reduced FA widespread in optic radiation, corona radiata, corpus callosum and other frontal, parietal and temporal regions in adults
- Most juvenile studies: non-significant differences or a non-persistent pattern of changes
- Majority of studies: reduced AD and MD in T1D vs controls; non-significant differences in RD
- Microstructural alterations associated with age, hyperglycemia, DKA and cognitive performance
Original publication
Central nervous system microstructural alterations in Type 1 diabetes mellitus: A systematic review of diffusion Tensor imaging studies. Diabetes Res Clin Pract. Published 31 March 2023. doi:10.
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