Cardiovascular mortality in patients with advanced chronic kidney disease with and without diabetes: a nationwide cohort study
Authors' conclusion
Diabetes, albuminuria, and anemia remained important risk factors of cardiovascular mortality whereas our data suggest a limitation of LDL-cholesterol as a predictor of cardiovascular mortality in advanced CKD.
Study context
- Population
- Persons aged ≥ 18 years with eGFR < 30 mL/min/1.73m2, Denmark, 2002–2018advanced chronic kidney disease (CKD)
- Participants
- 138,583 persons
- Exposure
- Advanced CKD with diabetes vs without diabetes vs matched general population
- Diabetesn = 32,698
- Outcome
- Cardiovascular mortality, standardized risk
- Follow-up
- 1 year
Methodological detailsage- and sex-matched general population comparison cohort, cause-specific Cox regression, standardized risks
- Age- and sex-matched general population comparison cohort
- Cause-specific Cox regression, standardized risks
Main finding
As reported in the abstract
Standardized 1-year risk of cardiovascular mortality
Observational data: associations, not effects.
Further findings
1-year cardiovascular mortality across CKD stages and age groups
- Risk higher with diabetes vs without diabetes across advanced CKD stages and age groups
- 1.1- to 2.8-fold
Albuminuria and anemia
- Associated with increased cardiovascular mortality risk regardless of diabetes status
LDL-C
- Inversely associated with cardiovascular mortality risk without diabetes; no clear association with diabetes
Original publication
Cardiovascular mortality in patients with advanced chronic kidney disease with and without diabetes: a nationwide cohort study. Cardiovasc Diabetol. Published 16 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →