Cardiovascular-liver-metabolic multimorbidity: preliminary insights into the associations with the triglyceride glucose index (triglyceride-glucose (TyG)), its obesity-derived indices and their effects on long-term survival
Authors' conclusion
The TyG and its obesity-derived indices, particularly TyG-WWI and TyG-CVAI, exhibited significant incremental value for identifying CLMM, with CLMM status also conferring elevated subsequent mortality risk. Incorporating these indices into primary prevention monitoring systems for chronic diseases could facilitate the identification of individuals at high risk for CLMM and mortality.
Study context
- Population
- Adults in a national cohort
- Participants
- 20,235 adults
- Exposure
- TyG and its obesity-derived indices for identifying cardiovascular-liver-metabolic multimorbidity (CLMM) and predicting mortality
- Outcome
- Association of TyG and obesity-derived indices with CLMM and discriminatory performance
Methodological detailsnational cohort, multi-stage sampling design, weighted logistic and Cox regression
- National cohort
- Multi-stage sampling design
- Weighted logistic and Cox regression
Main finding
As reported in the abstract
All indices: AUROC for CLMM identification
> 0.76
TyG-WWI and TyG-CVAI: best AUROC, with largest net reclassification and integrated discrimination improvement
> 0.83
Observational data: associations, not effects.
Further findings
Mortality · long-term
- CLMM status significantly amplified the mortality risk associated with TyG and its obesity-derived indices
XGBoost-SHAP analyses
- TyG-CVAI and TyG-WWI were the major contributing variables for discriminating CLMM status
Exploratory mechanistic analyses
- Glucose metabolism a core driver of CLMM development; inflammatory factors partially mediating
Original publication
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