Cardiometabolic Risk in Bilateral versus Unilateral Nonfunctioning Adrenal Incidentalomas: Evidence From a Large Referral Center Cohort
Authors' conclusion
Bilateral NFAIs are independently associated with greater cardiometabolic risk and complications compared to unilateral lesions.
Study context
- Population
- Outpatients with nonfunctioning adrenal incidentalomas (NFAIs) in primary cardiovascular prevention, diagnosed and treated at a tertiary referral center 2000–2024
- Participants
- 906 outpatients
- Exposure
- Bilateral vs unilateral NFAIs
- Bilateraln = 86
- Unilateraln = 820reference
- Outcome
- Cardiovascular risk assessed using validated scores
Methodological detailssingle-centre, tertiary referral center
- Single-centre
- Tertiary referral center
Main finding
As reported in the abstract
Cardiovascular risk scores (multivariable linear regression)
- Bilateral vs Unilateral: P = 0.006
- Bilateral vs Unilateral: P < 0.001
- Bilateral vs Unilateral: P < 0.001
- Bilateral vs Unilateral: P = 0.035
- Multivariable linear regressions
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Presence of T2D | 2.36 (1.18–4.72) | P = 0.015 | |
| Presence of organ damage | 2.09 (1.00–4.37) | P = 0.050 | |
| 0.20.5125Odds ratio (log scale) |
- Presence of T2D: multivariable logistic regression adjusted for age, male sex, BMI, smoking, arterial hypertension, number of antihypertensive drugs and eGFR
- Presence of organ damage: multivariable logistic regression adjusted for age, male sex, BMI, smoking, arterial hypertension and number of antihypertensive drugs
Original publication
Cardiometabolic Risk in Bilateral versus Unilateral Nonfunctioning Adrenal Incidentalomas: Evidence From a Large Referral Center Cohort. Endocr Pract. Published 23 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →