Cardiometabolic factors and population risks of cardiovascular disease in community‐dwelling adults with varied blood pressure statuses
Authors' conclusion
The awareness and control rates of hypertension were extremely low among Southern Chinese adults. BP status significantly modified the associations between cardiometabolic risk factors and CVD, and the overall PAFs for CVD were higher among people with normal BP. Dedicated efforts are needed to improve the management of cardiometabolic factors.
Study context
- Population
- Community-dwelling adults without prevalent cardiovascular disease (CVD), China PEACE Million Persons Project subcohort; 39.0% men, mean age 54.2 years; 26.6% Stage 1 and 30.8% Stage 2 hypertension
- Participants
- 94,183 adults
- Exposure
- Cardiometabolic risk factors and CVD across blood pressure (BP) groups
- Outcome
- Hospitalizations for CVD
- Follow-up
- Median 3.5 years
Methodological detailssubcohort of the China PEACE Million Persons Project
- Subcohort of the China PEACE Million Persons Project
Main finding
As reported in the abstract
Hospitalizations for CVD (6065 events)
- BP per 1-SD, HR
- 1.34 (1.29, 1.40) (95% CI)
- Fasting blood glucose (FBG) per 1-SD, HR
- 1.16 (1.14, 1.19) (95% CI)
- Waist circumference (WC) per 1-SD, HR
- 1.41 (1.36, 1.47) (95% CI)
- PAF for CVD, all cardiometabolic risk factors
- 35.6% (30.0, 40.8) (95% CI)
- PAF for CVD, BP control (highest among risk factors)
- 15.1% (8.2, 21.4) (95% CI)
Observational data: associations, not effects.
Further findings
Effect modification by BP status
- BP status modified associations of abdominal obesity, suboptimal body mass index (BMI), suboptimal heart rate and abnormal FBG with CVD; stronger in optimal BP groups vs hypertensive groups (p for risk factor-by-BP group interaction <0.05)
- Overall population-attributable fractions (PAFs) of cardiometabolic risk factors for CVD higher in normotensive vs hypertensive participants
Original publication
Cardiometabolic factors and population risks of cardiovascular disease in community‐dwelling adults with varied blood pressure statuses. Diabetes Obes Metab. Published 13 May 2024. doi:10.
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