Cardio-kidney-metabolic complexity in patients with atrial fibrillation: an analysis from the prospective GLORIA-AF registry phase III
Main finding · All-cause death and MACEResult — go to the resultHazard ratio 1.69 95% CI 1.20–2.37Authors' conclusion
In patients with AF, CKM domains are commonly found, and their prevalence is heterogeneous across geographical regions. CKM syndrome influences OAC use and had detrimental prognostic effects, with an increasing risk of all-cause death and MACE as the burden of CKM domains increased.
Study context
- Population
- Patients with atrial fibrillation (AF) and CHA2DS2-VASc score ≥ 1, GLORIA-AF Registry phase III; age 70.1 ± 10.4 years, 45.2% females
- Participants
- 16,070 patients
- Exposure
- Number and groups of cardio-Kidney-Metabolic (CKM) domains
- 3 CKM domainsn = 1,931
- Outcome
- Composite of:
- All-cause death
- MACE
- Follow-up
- 3-year follow-up
Methodological detailsglobal, multiple-adjusted regression analyses
- Global
- Multiple-adjusted regression analyses
Main finding
All-cause death and MACE
Hazard ratio
1.69
95% CI 1.20–2.37
3 CKM domainsvs 0 CKM domains
HR 1.69 (95% CI 1.20–2.37)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| OAC use2 CKM domainsvs 0 CKM domains | 1.40 (1.14–1.72) | |
| OAC use3 CKM domainsvs 0 CKM domains | 1.38 (1.07–1.78) | |
| 0.512Odds ratio (log scale) |
- Prevalence of all 3 CKM domains
- 12.0% · 1931
Prevalence of all 3 CKM domains
- Substantial geographical variation in the distribution of CKM domains
Groups of CKM domains and clinical outcomes
- Groups characterized by the kidney domain showed the highest association with the risk of clinical outcomes
Original publication
Cardio-kidney-metabolic complexity in patients with atrial fibrillation: an analysis from the prospective GLORIA-AF registry phase III. Cardiovasc Diabetol. Published 11 October 2025. doi:10.
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