Association between cholesterol, high-density lipoprotein, and glucose index and risks of cardiovascular and all-cause mortality in patients with calcific aortic valve stenosis: the ARISTOTLE cohort study
Authors' conclusion
Higher levels of insulin resistance, as assessed by the CHG index, are associated with increased risks of cardiovascular and all-cause mortality in patients with calcific aortic valve stenosis.
Study context
- Population
- Patients with calcific aortic valve stenosis diagnosed by echocardiography, First Affiliated Hospital of Sun Yat-sen University; mean age 68.91 ± 11.68 years, 56.6% male
- Participants
- 1,175 patients
- Exposure
- High vs low CHG index
- Outcome
- Cardiovascular mortality and all-cause mortality
- Follow-up
- Median 3.23 [1.15, 6.07] years
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Each 1-unit increase in CHG index: higher risk of cardiovascular mortality (fully adjusted model)
53%
Each 1-unit increase in CHG index: higher risk of all-cause mortality (fully adjusted model)
43%
High vs low CHG index: higher risk of cardiovascular mortality
1.44-fold
High vs low CHG index: higher risk of all-cause mortality
1.43-fold
Observational data: associations, not effects.
Further findings
Shape of association (restricted cubic spline)
- Linear relationship with cardiovascular mortality (p for nonlinearity)
- 0.529
- Linear relationship with all-cause mortality (p for nonlinearity)
- 0.436
Original publication
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