C-reactive protein-triglyceride glucose index in evaluating cardiovascular disease and all-cause mortality incidence among individuals across stages 0–3 of cardiovascular–kidney–metabolic syndrome: a nationwide prospective cohort study
Authors' conclusion
Findings show that higher CTI level significantly associated with CVD and death risk, highlighting its potential as a biomarker for individuals with CKM stages 0-3.
Study context
- Population
- Middle-aged and elderly people in cardiovascular-kidney-metabolic (CKM) syndrome stages 0–3, China Health and Retirement Longitudinal Study (CHARLS)5,723 cardiovascular disease (CVD)
- Participants
- 17,705 participants
- Exposure
- Higher vs lower C-reactive protein-triglyceride-glucose index
- Outcome
- Occurrence of CVD and overall mortality
Methodological detailsnationwide
- Nationwide
Main finding
As reported in the abstract
Increase in overall mortality risk per 1-unit rise in continuous CTI, fully adjusted
111%
Observational data: associations, not effects.
Original publication
C-reactive protein-triglyceride glucose index in evaluating cardiovascular disease and all-cause mortality incidence among individuals across stages 0–3 of cardiovascular–kidney–metabolic syndrome: a nationwide prospective cohort study. Cardiovasc Diabetol. Published 22 July 2025. doi:10.
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