C-reactive protein predicts endocortical expansion but not fracture in older men: the prospective STRAMBO study
Authors' conclusion
Higher hsCRP levels were associated with greater endocortical expansion at the distal radius and tibia. Higher hsCRP was associated with slightly faster decrease in total and cortical vBMD and failure load at distal tibia, but not with the fracture risk.
Study context
- Population
- Older men aged 60–88 (STRAMBO study)
- Participants
- 823 men
- Outcome
- Association of hsCRP with decrease in aBMD, bone microarchitecture decline (distal radius, distal tibia) and fracture risk
- Follow-up
- 4 and 8 years
Main finding
As reported in the abstract
Higher high-sensitivity C-reactive protein (hsCRP) associated with faster decrease in cortical area and more rapid increase in trabecular area, distal radius (mm²/year/SD)
0.048
p < 0.05
Higher hsCRP associated with faster decrease in cortical area and more rapid increase in trabecular area, distal tibia (mm²/year/SD)
0.123
p < 0.001
Observational data: associations, not effects.
Original publication
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