Burden of established cardiovascular disease in people with type 2 diabetes and matched controls: Hospital‐based care, days absent from work, costs and mortality
Authors' conclusion
The sizable burden of eCVD on both the individual with type 2 diabetes and society calls for efficient management in order to reduce the risks for those living with eCVD and to postpone its onset.
Study context
- Population
- People diagnosed with T2D before age 70 years and matched controls, Sweden, national registersT2D
- Participants
- 454,983 people
- Exposure
- T2D with and without established CVD vs matched controls
- T2D with established cardiovascular disease (eCVD)n = 136,135
- Outcome
- Burden of eCVD in T2D
Methodological detailscontrols matched 5:1, register-based
- Controls matched 5:1
- Register-based
Main finding
As reported in the abstract
- T2D with ≥1 person-year with eCVD
- 30% (n = 136 135 of 454 983); women 24%; men 34%
- Mean annual costs of hospital-based care for diabetes complications, EUR
- 2629 (95% CI 2601-2657)
- Of which attributed to eCVD, EUR
- 2337 (95% CI 2309-2365) (89%)
- Most costly person-years (10th percentile): share of T2D with eCVD
- 42%
- Days absent per year in T2D
- 146 (95% CI 145-147)
- Of which attributed to eCVD, days
- 68 (47%; 95% CI 67-70)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| MortalityT2D with eCVDvs Controls without eCVD | 4.63 (4.58–4.68) | |
| MortalityT2D without eCVDvs Controls without eCVD | 1.86 (1.84–1.88) | |
| 0.20.5125Hazard ratio (log scale) |
- Mortality: Cox regression stratified by birth year, adjusted for sex and education
Original publication
Burden of established cardiovascular disease in people with type 2 diabetes and matched controls: Hospital‐based care, days absent from work, costs and mortality. Diabetes Obes Metab. Published 28 November 2022. doi:10.
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