Bringing early detection to life: real-world operationalization of a presymptomatic type 1 diabetes screening and monitoring pilot program
Authors' conclusion
Findings from this pilot offer critical insights into the practical implementation of presymptomatic type 1 diabetes screening and monitoring programs in diverse clinical environments. Despite identified barriers, continuous quality improvement efforts, along with identified facilitators to success, led to an increase in the number of individuals screened and monitored. Future work will focus on expanding these efforts across diverse care settings, with strategies to support sustainability beyond pilot phases.
Study context
- Population
- Individuals screened for presymptomatic T1D with islet autoantibody testing in routine care at two pediatric T1D Exchange Quality Improvement Collaborative (T1DX-QI) centers; T1DX-QI centers surveyed for readinessscreened
- Participants
- 147 individuals
- Outcome
- Operational feasibility of integrating presymptomatic T1D screening and monitoring into routine clinical care
Methodological detailsproof of concept, two pediatric centers, focus groups, cross-sectional readiness survey, 18-month period
- Proof of concept
- Two pediatric centers
- Focus groups
- Cross-sectional readiness survey
- 18-month period
Main finding
As reported in the abstract
Individuals screened
147
Observational data: associations, not effects.
Further findings
Focus groups: care team perceptions of operational challenges
- Facilitators: enhanced interdisciplinary communication, streamlined insurance processes, improved electronic health record systems
- Challenges: limited clinical resources, variable patient engagement, inconsistent insurance coverage
Readiness survey of T1DX-QI centers · prior to project start
- Pediatric centers were twice as likely to conduct screening and reported greater access to results from research screening programs
Safety
DKA among those screened with confirmed positive results
- Episodes of DKA
- 0
Original publication
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