Bone marrow metabolism is affected by body weight and response to exercise training varies according to anatomical location
Authors' conclusion
In this study, regular exercise training increases femoral BM GU regardless of weight and genetics. Interestingly, lumbar vertebral BM GU is higher in participants with higher body weight, and training counteracts this effect in heavier co-twins even without reduction in weight. These data suggest that BM metabolism is altered by physical activity.
Study context
- Population
- Monozygotic twin pairs discordant for body weight; mean ± SD age 40.4 ± 4.5 years; BMI 32.9 ± 7.6, mean difference between co-twins 7.6 kg/m²; eight female pairs12 twin pairs
- Comparison
- Heavier vs leaner co-twins; before vs after exercise training
- Outcome
- Lumbar vertebral and femoral BM insulin-stimulated glucose uptake (GU) by 18 F-FDG PET
Methodological detailsmonozygotic twin pairs discordant for body weight, 6-month exercise training intervention
- Monozygotic twin pairs discordant for body weight
- 6-month exercise training intervention
Main finding
As reported in the abstract
BM insulin-stimulated GU
- Baseline: heavier co-twins had higher lumbar vertebral bone marrow (BM) glucose uptake (GU) than leaner co-twins
- p < .001
- Training improved femoral BM GU
- p = .008
- Training response in lumbar vertebral BM GU differed between groups (time × group)
- p = .02
- Lumbar vertebral BM GU tended to decrease in heavier co-twins with training
- p = .06
Further findings
Bone turnover markers and BMD at baseline
- Lower bone turnover markers in heavier vs leaner co-twins
- all p < .01
- No significant difference in BMD
Whole-body insulin sensitivity and aerobic capacity · 6 months
- Training improved whole-body insulin sensitivity and aerobic capacity
- both p < .05
Original publication
Bone marrow metabolism is affected by body weight and response to exercise training varies according to anatomical location. Diabetes Obes Metab. Published 11 October 2023. doi:10.
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