Body Roundness Index Associated With Cardiometabolic Multimorbidity and Mortality: A Multistate Model
Authors' conclusion
Our findings emphasize dynamic BRI monitoring as a biomarker for early CMM risk identification and prognostic assessment, necessitating disease- and sex-specific prevention strategies.
Study context
- Population
- Participants of the Kailuan cohortKailuan cohort
- Participants
- 87,902 participants
- Exposure
- Highest vs lowest body roundness index (BRI) quartile
- Outcome
- First occurrence of cardiometabolic disease (FCMD), cardiometabolic multimorbidity (CMM) and all-cause mortality, across CMM progression
- Follow-up
- Median 13.68 years
Methodological detailsmultistate model, BRI quartiles
- Multistate model
- BRI quartiles
Main finding
As reported in the abstract
Transitions across CMM progression (multistate model)
Highest BRI quartile vs Lowest BRI quartileHazard ratio (CI)
healthy-to-FCMD transition
2.08(1.99–2.17)
FCMD-to-CMM transition
1.61(1.38–1.88)
Mortality from healthy state
1.09(1.03–1.16)
Mortality from FCMD
0.99(0.89–1.10)
Mortality from CMM
0.73(0.54–0.99)
- Developed FCMD
- 21,636
- Developed cardiometabolic multimorbidity (CMM)
- 2114
- Died
- 14,782
Observational data: associations, not effects.
Further findings
Subgroups by disease type and sex
- BRI's impact varied by disease type (DM, MI, stroke) and sex, with stronger associations in females
Original publication
Body Roundness Index Associated With Cardiometabolic Multimorbidity and Mortality: A Multistate Model. Obesity (Silver Spring). Published 28 September 2025. doi:10.
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