Body mass index at birth and early life and colorectal cancer: A two‐sample Mendelian randomization analysis in European and East Asian genetic similarity populations
Authors' conclusion
We found little evidence of any associations between early life adiposity on later life CRC risk.
Study context
- Population
- Body mass index (BMI) genome-wide association study (GWAS) in 28,681 children (MoBa) applied to colorectal cancer (CRC) GWAS data from European and East Asian descent populations102,893 cases · 485,083 non-cases
- Comparison
- Genetically predicted early-life BMI and CRC risk
- Outcome
- CRC risk
Methodological detailsEuropean and East Asian genetic similarity populations
- European and East Asian genetic similarity populations
Main finding
As reported in the abstract
CRC risk per 1-SD increase in early life BMI
Europeans: OR per 1-SD increase
1.01
95% CI 0.95, 1.07
East Asians: OR per 1-SD increase
1.02
95% CI 0.91, 1.14
Further findings
BMI at specific childhood time points and cancer-site-specific analyses
- Similar nonsignificant associations
Original publication
Body mass index at birth and early life and colorectal cancer: A two‐sample Mendelian randomization analysis in European and East Asian genetic similarity populations. Pediatr Obes. Published 25 November 2024. doi:10.
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