Birth Weight, Cardiometabolic Factors, and Coronary Heart Disease: A Mendelian Randomization Study
Authors' conclusion
Our findings supported that lower BW increased CHD risk and revealed that fetal-specific and maternal-specific BW may both contribute to this effect. The causality between BW and CHD was mediated by several cardiometabolic factors.
Study context
- Population
- GWAS summary-level data: own birth weight (BW), offspring BW (N = 210,267 mothers), 16 cardiometabolic factors; Coronary heart disease (CHD) 60,801 cases and 123,504 controls, mixed ancestry60,801 cases · 123,504 controls · own BW 298,142
- Comparison
- Genetically predicted lower BW and CHD risk
- Outcome
- Causal effect of BW on CHD
Methodological detailstwo-step MR mediation analysis, inverse variance weighted analysis
- Two-step MR mediation analysis
- Inverse variance weighted analysis
Main finding
As reported in the abstract
CHD risk per lower BW
Lower BW raised CHD risk (inverse variance weighted), β (95% CI −0.40, −0.20)
−.30
Further findings
Mediation by cardiometabolic factors
- Mediators identified (BMI-adjusted hip circumference, TG, fasting insulin, diastolic BP, systolic blood pressure (SBP))
- 5
- Mediated proportion, TG
- 7.44%
- Mediated proportion, SBP
- 27.75%
- Fetal-specific BW–CHD causality mediated by glycemic factors; maternal-specific by SBP
Original publication
Birth Weight, Cardiometabolic Factors, and Coronary Heart Disease: A Mendelian Randomization Study. J Clin Endocrinol Metab. Published 29 May 2023. doi:10.
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