Biomarkers in the Newborn with Fetal Growth Retardation and Early Impairment of Heart Function
Authors' conclusion
PEA successfully identified both established and novel proteins associated with fetal growth and birth size, including one novel protein related to LVLS. This indicates that our approach is promising for uncovering biological pathways that may be involved in direct programming of cardiovascular function in children and affect the risk of cardiovascular disease in adulthood.
Study context
- Population
- Newborns; cord blood plasma levels of 184 circulating proteins related to birth weight SDS and left ventricular longitudinal strain (LVLS)
- Participants
- 48 newborns
- Outcome
- Cardiovascular protein biomarkers associated with birth weight SDS
Methodological detailscord blood proteomics (Proximity Extension Assay), echocardiography at birth and 3 months
- Cord blood proteomics (Proximity Extension Assay)
- Echocardiography at birth and 3 months
Main finding
As reported in the abstract
- Cardiovascular protein biomarkers associated with birth weight SDS: stem cell factor, leptin, elafin, insulin-like growth factor-binding protein-1, follastatin, paraoxonase, epithelial cell adhesion molecule (Ep-CAM)
- seven
Observational data: associations, not effects.
Original publication
Biomarkers in the Newborn with Fetal Growth Retardation and Early Impairment of Heart Function. Horm Res Paediatr. Published 26 August 2025. doi:10.
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