Biological aging mediates the associations of metabolic score for insulin resistance with all‐cause and cardiovascular disease mortality among US adults: A nationwide cohort study
Authors' conclusion
This study highlights the detrimental effects of insulin resistance, as measured by METS-IR, on all-cause and CVD mortality. Moreover, it underscores the role of biological ageing in mediating these associations, emphasizing the need for interventions targeting both insulin resistance and ageing processes to mitigate mortality risks in metabolic disorders.
Study context
- Population
- US adults, National Health and Nutrition Examination Survey (NHANES) 1999–2018
- Participants
- 19,204 adults
- Exposure
- Highest vs lowest metabolic score for insulin resistance (METS-IR) level
- Outcome
- All-cause and CVD-specific mortality
- Follow-up
- Median 9.17 years
Methodological detailsnationwide, NHANES 1999-2018, mediation analysis
- Nationwide
- NHANES 1999-2018
- Mediation analysis
Main finding
As reported in the abstract
Each group vs Q1Estimate (95% CI)
Q4
HR (all-cause mortality) 1.38(1.14–1.67)
Q4
HR (CVD mortality) 1.52(1.10–2.12)
- Deaths
- 2818
- Cardiovascular disease (CVD)-specific deaths
- 875
Observational data: associations, not effects.
Further findings
Dose-response (restricted cubic splines)
- Nonlinear relationship with all-cause mortality; only METS-IR above threshold positively correlated with all-cause death
- 41.02 μg/L
- Linear positive relationship with CVD mortality
Mediation by phenotypic age (PhenoAge)
- Proportion mediated, all-cause mortality
- 51.32% (p < 0.001)
- Proportion mediated, CVD-specific mortality
- 41.77% (p < 0.001)
Mediation by biological age (BioAge)
- Proportion mediated, all-cause mortality
- 21.33% (p < 0.001)
- Proportion mediated, CVD-specific mortality
- 15.88% (p < 0.001)
Original publication
Biological aging mediates the associations of metabolic score for insulin resistance with all‐cause and cardiovascular disease mortality among US adults: A nationwide cohort study. Diabetes Obes Metab. Published 9 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →