Automated Insulin Delivery Systems in Type 2 Diabetes Mellitus: A Systematic Review and Meta-analysis
Authors' conclusion
AID systems improved glucose control in a diverse population of individuals with type 2 diabetes requiring insulin therapy with reduction in hypoglycemia. These findings support recommendations for AID systems use in future type 2 diabetes management guidelines.
Study context
- Population
- People with T2D requiring insulin; studies reporting CGM outcomes
- Participants
- 1,530 people9 studies
- Comparison
- Automated insulin delivery (AID) systems
- Outcome
- Glycemic outcomes: TIR (70-180 mg/dL), TAR, TBR, mean glucose, HbA1c
Methodological detailssingle-arm meta-analysis, random-effects model, Only three RCTs; heterogeneous designs; imputed missing data
- Single-arm meta-analysis
- Random-effects model
- Only three RCTs; heterogeneous designs; imputed missing data
Pooled result
As reported in the abstract
Change with AID
- Time in range (TIR) increase
- 16.06% (95% CI 10.48-21.65)
- Time above range (TAR) change
- −15.90% (95% CI −21.44 to −10.36)
- HbA1c change
- −1.27% (95% CI −2.06 to −0.48)
- Mean glucose change
- −21.34 mg/dL (95% CI −32.06 to −10.62)
- Mean glucose change, mmol/L
- 1.19 mmol/L (95% CI −1.78 to −0.59)
Further pooled results
- No changes in body weight or BMI
Original publication
Automated Insulin Delivery Systems in Type 2 Diabetes Mellitus: A Systematic Review and Meta-analysis. Diabetes Care. Published 6 April 2026. doi:10.
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