Automated bone age calculation is an independent predictor of vertebral fracture burden in Duchenne muscular dystrophy
Performance · BA delayResult — go to the resultIntraclass correlation coefficient 0.978 95% CI 0.961–0.987Authors' conclusion
BoneXpert provided BA results that were similar to those generated by radiologists in individuals with DMD and that retained the clinically relevant association between BA delay and VF. We also demonstrated that lower BHI Z-scores in individuals with DMD were associated with spinal fragility.
Study context
- Population
- Males with Duchenne muscular dystrophy (DMD); CA 11.6 ± 3.8 years (mean ± SD); left-hand radiographs
- Participants
- 54 left-hand radiographs
- Comparison
- BoneXpert vs experienced radiologists for bone age (BA) assessment
- Outcome
- Agreement of BA by radiologists vs BoneXpert; association of BA delay and BHI with SDI (VF burden)
Performance
BA delay
Intraclass correlation coefficient
0.978
95% CI 0.961–0.987
P = 0.138
By group
Radiologists
−1.9
mean · SD 2.4 · years
BoneXpert
−1.8
mean · SD 2.4 · years
As reported in the abstract
Further findings
| Outcome | BoneXpert | Radiologists |
|---|---|---|
| IRR for SDI per 1-year BA delay (multivariable Poisson regression) | ||
| IRR | 1.5 (95% CI, 1.1-2.1; p = 0.009) | 1.8 (95% CI, 1.3-2.5; p = 0.001) |
IRR for SDI per 1.0 unit decrease in Bone Health Index (BHI) Z-score (BoneXpert)
- IRR
- 2.9 (95% CI, 2.0-4.2; p < 0.001)
- Separate model
Original publication
Automated bone age calculation is an independent predictor of vertebral fracture burden in Duchenne muscular dystrophy. Osteoporos Int. Published 21 October 2025. doi:10.
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