Autoimmune Thyroid Disease in a Cohort of Children With Increased Genetic Susceptibility to Type 1 Diabetes: The Environmental Determinants of Diabetes in the Young Study
Authors' conclusion
Female sex, family history of autoimmune disease, and HLA haplogenotype are risk factors for AITD in genetically high-risk children, but these trends differ for progression from thyroid autoimmunity to AITD.
Study context
- Population
- Children with increased genetic susceptibility for T1D (TEDDY Study), followed to age 15 years; screened for thyroid autoantibodies at ages 9 and 145,203 screened
- Participants
- 8,676 children
- Outcome
- Clinical autoimmune thyroid disease (AITD): hypothyroidism or hyperthyroidism diagnoses and AITD medications
Methodological detailsHypo- and hyperthyroidism diagnoses and autoimmune thyroid disease (AITD) medications reported at every visit, 2 to 4 times per year; positive autoantibody screens prompted retrospective analysis of earlier samples to date autoantibody onset
- Hypo- and hyperthyroidism diagnoses and AITD medications reported at every visit, 2 to 4 times per year; positive autoantibody screens prompted retrospective analysis of earlier samples to date autoantibody onset
Main finding
As reported in the abstract
Diagnosed with AITD among children screened for thyroid autoantibodies
99 of 5203
Observational data: associations, not effects.
Further findings
Factors associated with AITD among children positive for thyroid autoantibodies
- Children positive for thyroid autoantibodies
- 575
- Human leukocyte antigen (HLA) remained associated with AITD; family history estimates attenuated; no association for sex
Original publication
Autoimmune Thyroid Disease in a Cohort of Children With Increased Genetic Susceptibility to Type 1 Diabetes: The Environmental Determinants of Diabetes in the Young Study. Clin Endocrinol (Oxf). Published 15 December 2025. doi:10.
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