Autoantibody-Positive versus Autoantibody-Negative Type 1 Diabetes in Children: Clinical and Biochemical Characteristics
Authors' conclusion
In our study, autoantibody-positive and -negative T1DM patients were similar. This implies that both patient groups can be approached in the same way regarding treatment, education, and prognosis. Misdiagnosis of monogenic causes within T1DM could occur; therefore, clinicians should be aware of and perform genetic tests according to international guidelines.
Study context
- Population
- Patients diagnosed with T1D before age 18 years, Dutch pediatric diabetes clinic (Diaboss, OLVG hospital)recruited
- Participants
- 562 patients
- Exposure
- Autoantibody-positive vs autoantibody-negative T1D in children
- Autoantibody negativen = 66reference
- Outcome
- Differences in clinical and biochemical characteristics
Methodological detailsmonocenter
- Monocenter
Main finding
As reported in the abstract
Demographic and clinical characteristics, presentation, long-term regulation
- No significant differences in demographic and clinical characteristics, diabetes presentation, and long-term diabetes regulation between autoantibody-positive and autoantibody-negative patients
Observational data: associations, not effects.
Further findings
Genetic testing for monogenic causes in autoantibody-negative patients
- Monogenic causes ruled out by genetic testing
- 15 of 66 (23%)
- Not tested
- 51 (77%)
- Positive family history for diabetes more likely to be tested
- P = 0.002
Monogenic cause of diabetes found at a later stage (excluded)
- Tested positive for a monogenic cause
- 8 of 562 (1.4%)
- Autoantibody-positive patients solely anti-ICA positive (excluded)
- 11 of 488 (2.2%)
Original publication
Autoantibody-Positive versus Autoantibody-Negative Type 1 Diabetes in Children: Clinical and Biochemical Characteristics. Horm Res Paediatr. Published 3 March 2026. doi:10.
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