At-Home Use of a Pregnancy-Specific Zone-MPC Closed-Loop System for Pregnancies Complicated by Type 1 Diabetes: A Single-Arm, Observational Multicenter Study
Main finding · TIR 63-140 mg/dLResult — go to the resultIncrease 14.1 percentage pointsAuthors' conclusion
The results show that the extended use of CLC-P at home until delivery is feasible. Larger, randomized studies are needed to further evaluate system efficacy and pregnancy outcomes.
Study context
- Population
- Pregnant women with T1D using insulin pumps, enrolled in the second or early third trimester; HbA1c 5.8 ± 0.6%, mean gestational age 23.7 ± 3.5 weeks at system start
- Participants
- 10 women
- Exposure
- CLC-P vs run-in on personal pump therapy
- Outcome
- CGM percentage of time in target range 63-140 mg/dL vs run-in
Methodological detailsat-home use, Meals and activities unrestricted; system run on an unlocked smartphone at home after 2 days of supervised training
- At-home use
- Meals and activities unrestricted; system run on an unlocked smartphone at home after 2 days of supervised training
Main finding
TIR 63-140 mg/dL
Increase
14.1 percentage points
P = 0.002
By group
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Values | P value |
|---|---|---|
| Time over 140 mg/dLCLC-P vs Run-in · significant decrease with CLC-P | P = 0.033 | |
| Time <63 mg/dL and <54 mg/dLCLC-P vs Run-in · significant decrease with CLC-P | P = 0.037 for both | |
| Exceeded consensus goal of >70% TIR during CLC-P | CLC-P 9 events |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
At-Home Use of a Pregnancy-Specific Zone-MPC Closed-Loop System for Pregnancies Complicated by Type 1 Diabetes: A Single-Arm, Observational Multicenter Study. Diabetes Care. Published 17 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →