Associations of triglyceride glucose-body mass index and the combination of sedentary behavior and physical activity with risks of all-cause mortality and myocardial infarction: a cohort study from the UK biobank
Authors' conclusion
TyG-BMI index and the combination of SB and PA were independently and jointly associated with risks of all-cause mortality and MI. Our findings highlight the importance of improving insulin resistance to reduce all-cause mortality risk, particularly in individuals with long-term SB and insufficient PA, who are more susceptible to the adverse effects of TyG-BMI index. In long-term sedentary individuals, meeting PA guidelines (≥ 150 min/wk of MVPA) effectively mitigated risks of all-cause mortality and MI associated with TyG-BMI index.
Study context
- Population
- UK Biobank participantseligible of 502,356
- Participants
- 297,761 participants
- Exposure
- TyG-BMI tertiles combined with sedentary behavior (SB) & moderate to vigorous physical activity (MVPA) categories
- Outcome
- All-cause mortality and MI
- Follow-up
- Median 13.8 and 13.6 years
Methodological detailsUK Biobank, Cox proportional hazards model, restricted cubic spline regression
- UK Biobank
- Cox proportional hazards model
- Restricted cubic spline regression
Main finding
As reported in the abstract
Events: deaths
21 335
Events: MI
9 116
All-cause mortality: U-shaped relationship, cut-off point
225.09
MI: positive nonlinear relationship, cut-off point
266.87
Observational data: associations, not effects.
Further findings
Interaction: TyG-BMI tertile 1 and ≥6 h/d SB & <150 min/wk MVPA on all-cause mortality
- Synergistic effect on all-cause mortality
- P for interaction < 0.001
All-cause mortality, TyG-BMI tertile 2 with MVPA ≥150 min/wk
- No significant association; <6 h/d SB, HR
- 0.98 (0.93-1.03) (95% CI)
- No significant association; ≥6 h/d SB, HR
- 1.00 (0.94-1.07) (95% CI)
MI, TyG-BMI tertile 1 with one healthy behaviour
- No significant association; <6 h/d SB with <150 min/wk MVPA, HR
- 1.07(0.95-1.20) (95% CI)
- No significant association; ≥150 min/wk MVPA with ≥6 h/d SB, HR
- 1.09(0.94-1.25) (95% CI)
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →