Associations of Changes in Weight and Relative Fat Mass With All‐Cause and Cardiovascular Disease Mortality Among Older Community‐Dwellers in Guangzhou, China
Authors' conclusion
Weight change exceeding 10% and any RFM decrease are associated with elevated all-cause and CVD mortality among older community-dwellers. Concurrent changes of more than 10% in both metrics confer the greatest risk.
Study context
- Population
- Guangzhou residents aged ≥ 65 years (mean 71.9 years) with weight, waist and height measured in 2018 and repeat assessment in 2019–2020
- Participants
- 203,962 residents
- Exposure
- Changes in weight and relative fat mass (RFM) vs stable weight/RFM
- Outcome
- All-cause and CVD mortality
- Follow-up
- Median 5.6 years
Methodological detailscommunity-based, repeat assessment
- Community-based
- Repeat assessment
Main finding
As reported in the abstract
All-cause mortality by weight change
Each group vs stableHazard ratio (95% CI)
> 10% decrease
1.89(1.76–2.03)
> 10% increase
1.50(1.39–1.63)
- Deaths: all-cause
- 14 712
- Deaths: Cardiovascular disease (CVD)
- 6536
Observational data: associations, not effects.
Further findings
| Outcome | HR (CI) | |
|---|---|---|
| Joint weight and RFM change: all-cause mortalityWeight and RFM both decreased > 10%vs StableHighest all-cause mortality risk | 2.09 (1.82–2.41) | |
| Joint weight and RFM change: CVD mortality> 10% weight decrease with > 10% RFM increasevs StableHighest CVD risk | 2.02 (1.53–2.67) | |
| 0.20.5125Hazard ratio (log scale) |
Subgroups
- Similar associations observed in different subgroups
Original publication
Associations of Changes in Weight and Relative Fat Mass With All‐Cause and Cardiovascular Disease Mortality Among Older Community‐Dwellers in Guangzhou, China. Diabetes Obes Metab. Published 1 June 2026. doi:10.
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