Association of the triglyceride-glucose index with early-onset atherosclerotic cardiovascular disease events and all-cause mortality: a prospective cohort study
Authors' conclusion
A higher TyG index is significantly associated with an increased incidence of early-onset ASCVD events and all-cause mortality in a young and middle-aged population from North China.
Study context
- Population
- Young and middle-aged people who participated in the 2006 Kailuan Study physical examination, North China
- Participants
- 64,489 participants
- Exposure
- Higher vs lower triglyceride glucose (TyG) index
- Outcome
- Early-onset ASCVD events and all-cause mortality
- Follow-up
- median 11-year follow-up
Main finding
As reported in the abstract
- Participants with at least one atherosclerotic cardiovascular disease (ASCVD) event
- 1984 (3.08%)
- Participants with all-cause death
- 1,392 (2.16%)
- Higher TyG index and early-onset ASCVD events, HR
- 1.61 (1.38-1.89) (95% CI)
- Higher TyG index and all-cause mortality, HR
- 1.39 (1.17-1.65) (95% CI)
- Increase in risk of early-onset ASCVD events per unit increase in TyG index
- 20%
Observational data: associations, not effects.
Further findings
Shape of association (restricted cubic spline)
- Non-linear association between TyG index and early-onset ASCVD events
- P for non-linear < 0.01
- Linear association between TyG index and all-cause mortality
- P for non-linear = 0.476
Original publication
Association of the triglyceride-glucose index with early-onset atherosclerotic cardiovascular disease events and all-cause mortality: a prospective cohort study. Cardiovasc Diabetol. Published 29 April 2024. doi:10.
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